Colonic immune cells in irritable bowel syndrome: A systematic review and meta-analysis.

Mohammad BashashatiS MoossaviCesare CremonM R BarbaroS MoravejiG TalmonN RezaeiP A HughesZhao-Xiang BianC H ChoiO Y LeeM CoëffierL ChangL OhmanM J SchmulsonR W McCallumM SimrenK A SharkeyG Barbara

Published in: Neurogastroenterology and motility : the official journal of the European Gastrointestinal Motility Society (2017)

Mast cells and CD3+ T cells are increased in colonic biopsies of patients with IBS vs non-inflamed controls. These changes are segmental and sometimes IBS-subtype dependent. The diagnostic value of the quantification of colonic mucosal cells in IBS requires further investigation.

Keyphrases

irritable bowel syndrome
ulcerative colitis
induced apoptosis
cell cycle arrest
signaling pathway
cell proliferation