Genetic variation in CYB5R3 is associated with methemoglobin levels in preterm infants receiving nitric oxide therapy.

Tyson D FullerCassandra N SpracklenKelli K RyckmanLindsey A KnakeTamara D BuschAllison M MomanyJeffrey C MurrayJohn M Dagle

Published in: Pediatric research (2014)

We demonstrate a novel genetic association with neonatal MetHb levels. Identification of genetic risk factors may be useful in determining which preterm infants are most at risk of developing MetHb toxicity with the use of iNO.

Keyphrases

preterm infants
low birth weight
nitric oxide
risk factors
genome wide
oxidative stress
stem cells
dna methylation
hydrogen peroxide
nitric oxide synthase
gene expression
bone marrow
preterm birth