Nocardia farcinica Brain Abscess in a Multiple Myeloma Patient Treated with Proteasome Inhibitor: A Case Report and Review of the Literature.
Nengwen XuLinjie LiWen LeiWeidong HanPublished in: Brain sciences (2021)
Nocardia brain abscess is relatively rare, accounting for about 1-2% of all brain abscesses, and its mortality rate is three times higher than of other types of bacterial brain abscesses; thus, early diagnosis and treatment are essential. Nocardia brain abscess generally occurs in immunodeficient patients. We report a case of Nocardia farcinica brain abscess in a multiple myeloma patient treated with proteasome inhibitor (bortezomib and ixazomib), cyclophosphamide, and corticosteroid. The patient was treated with ceftriaxone and trimethoprim-sulfamethoxazole, together with drainage of the brain abscess. Regular brain MRI follow-ups showed that intracranial lesions were gradually absorbed and improved.
Keyphrases
- resting state
- white matter
- multiple myeloma
- functional connectivity
- cerebral ischemia
- newly diagnosed
- type diabetes
- magnetic resonance imaging
- end stage renal disease
- magnetic resonance
- low dose
- multiple sclerosis
- computed tomography
- microbial community
- brain injury
- risk factors
- cardiovascular events
- ultrasound guided
- patient reported