Investigating key factors underlying neurodegeneration linked to alpha-synuclein spread.
Cindy C C PangMaja H SørensenKrit LeeKelvin C LukJohn Q TrojanowskiVirginia M Y LeeWendy NobleRaymond Chuen-Chung ChangPublished in: Neuropathology and applied neurobiology (2022)
Our results demonstrate that spread/replication and slow accumulation of pathological aSyn may not be sufficient to induce neurodegenerative changes. In contrast, oxidative stress responses in addition to aSyn accumulation were associated with other Parkinson's disease (PD)-associated abnormalities and cognitive dysfunction. Our results may be important when considering why only some PD patients develop dementia.