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HLA Genotyping in Children With Celiac Disease Allows to Establish the Risk of Developing Type 1 Diabetes.

Enrico SchirruRossano RossinoDaniela DianaRita D JoresDavide BalderaSandro MuntoniClaudia SpigaCarlo RipoliMaria R RicciardiFrancesco CuccaMauro Congia
Published in: Clinical and translational gastroenterology (2024)
CD is a condition for future T1D development, and specific HLA genotypes can predict this risk. Early screening for celiac autoimmunity and subsequent HLA typing in CD children could help identify those at high risk of T1D, allowing for proactive interventions and immunotherapies to preserve β-cell function. These findings may support the re-evaluation of HLA typing in children with CD.
Keyphrases
  • celiac disease
  • type diabetes
  • young adults
  • physical activity
  • genetic diversity
  • gene expression
  • genome wide
  • current status
  • skeletal muscle
  • weight loss