The role of myocardial blood volume in the pathophysiology of angina with non-obstructed coronary arteries: The MICORDIS study.

Caitlin E M VinkElize A M de JongJanneke WoudstraMitchel MolenaarOtto KampMarco J W GötteDaniel H van RaalteErik SernéTim P van de HoefSteven A J ChamuleauEtto C EringaYolande Appelman

Published in: International journal of cardiology (2024)

In ANOCA patients MBV is diminished at baseline, during hyperinsulinemia and dobutamine-induced stress in the absence of differences in microvascular recruitment. These findings support the presence of capillary rarefaction in ANOCA patients. ANOCA patients showed metabolic insulin resistance, but insulin did not acutely alter myocardial perfusion.

Keyphrases

end stage renal disease
ejection fraction
insulin resistance
type diabetes
coronary artery disease
coronary artery
patient reported outcomes
skeletal muscle
high fat diet
endothelial cells
acute coronary syndrome
glycemic control
aortic stenosis
aortic valve