Peculiar nuclear atypia associated with MDM2 gene amplification in carcinoma ex-pleomorphic adenoma harbouring an alteration of HMGA2.

Ziyad AlsugairMaxime FieuxFrançoise DescotesJonathan LopezCarolle CordonnierJuliette RusselAnne ChampagnacDaniel PissalouxPhilippe CérusePierre PhilouzeNazim Benzerdjeb

Published in: Histopathology (2024)

Our findings suggest a strong correlation between HMGA2 alteration/MDM2 amplification and a peculiar nuclear atypia, advocating for their evaluation in biphasic tumours to facilitate accurate diagnosis and tailored posttumour removal monitoring. Further studies are warranted to validate these observations and elucidate their prognostic implications.

Keyphrases

nucleic acid
genome wide
high resolution
copy number
label free
smoking cessation
case control
dna methylation
mass spectrometry
transcription factor