CRAMP deficiency leads to a pro-inflammatory phenotype and impaired phagocytosis after exposure to bacterial meningitis pathogens.
Eugenia KressJulika MerresLea-Jessica AlbrechtSven HammerschmidtThomas PufeSimone C TauberLars-Ove BrandenburgPublished in: Cell communication and signaling : CCS (2017)
In conclusion, the present study detected severe alterations of the glial immune response due to lack of CRAMP. The results indicate the importance of CRAMP to maintain and regulate the delicate balance between beneficial and harmful immune response in the brain.