Brain delivery enabled by transient blood-brain barrier disruption induced by regadenoson: a PET imaging study.
Benoit HostenSébastien GoutalSarah LeterrierCassandre CorvoLouise BreuilOlivier BarretSimon SpecklinCharles TruilletNicolas TournierPublished in: Expert opinion on drug delivery (2024)
PET imaging showed the features and limitations of BBB disruption induced by regadenoson in terms of extent, regional distribution, and reversibility. Nevertheless, regadenoson enables the brain delivery of small molecules or nanoparticles in rats.