Redefining the Incidence and Profile of Fluoropyrimidine-Associated Cardiotoxicity in Cancer Patients: A Systematic Review and Meta-Analysis.

Yajie LuWei PanShizhou DengQiongyi DouXiangxu WangQiang AnXiaowen WangHongchen JiYue HeiYan ChenJingyue YangHong-Mei Zhang

Published in: Pharmaceuticals (Basel, Switzerland) (2023)

Our study provides comprehensive global data on the incidence and profile of FAC. Different cancer types and treatment appear to have varying cardiotoxicities. Combination therapy, high cumulative dose, addition of anthracyclines, and pre-existing heart disease potentially increase the risk of FAC.

Keyphrases

combination therapy
risk factors
papillary thyroid
pulmonary hypertension
machine learning
squamous cell
squamous cell carcinoma
electronic health record
big data
lymph node metastasis
young adults
early breast cancer