Inhibition of Histone Deacetylase Activity Increases Cisplatin Efficacy to Eliminate Metastatic Cells in Pediatric Liver Cancers.

Ruhi Gulati Yasmeen FleifilKatherine JenningsAlexander J BondocGreg TiaoJames GellerLubov TimchenkoNikolai Timchenko

Published in: Cancers (2024)

Our studies demonstrate the synergistic benefits of HDAC inhibition and cisplatin to eliminate metastasis-initiating cells in pediatric liver cancers.

Keyphrases

histone deacetylase
induced apoptosis
cell cycle arrest
squamous cell carcinoma
small cell lung cancer
endoplasmic reticulum stress
signaling pathway
cell proliferation
young adults