Curcumin suppresses epithelial-to-mesenchymal transition of peritoneal mesothelial cells (HMrSV5) through regulation of transforming growth factor-activated kinase 1 (TAK1).

Jun-Li ZhaoMei-Zi GuoJun-Jun ZhuTing ZhangDan-Yan Min

Published in: Cellular & molecular biology letters (2019)

Our results demonstrate that curcumin showed an obvious protective effect on PDS-induced EMT of HMrSV5 cells and suggest implication of the TAK1, p38 and JNK pathway in mediating the effects of curcumin in EMT of MCs.

Keyphrases

induced apoptosis
transforming growth factor
epithelial mesenchymal transition
signaling pathway
cell cycle arrest
endoplasmic reticulum stress
cell death
high glucose
diabetic rats
endothelial cells
pi k akt
cell proliferation