H3K27 trimethylation loss in malignant peripheral nerve sheath tumor: a systematic review and meta-analysis with diagnostic implications.

Victor M LuTomas MarekHannah E GilderRoss C PufferAditya RaghunathanRobert J SpinnerDavid J Daniels

Published in: Journal of neuro-oncology (2019)

The incidence of complete H3K27me3 loss is substantial in high-grade MPNSTs and is low in MPNST-mimics. Greater cohort study and biological investigation will validate the certainty of these findings as well as elucidate their true molecular and clinical significances.

Keyphrases

peripheral nerve
high grade
low grade
risk factors
single molecule