Attenuation of adjuvant-induced arthritis with carnosic acid by inhibiting mPGES-1, COX-2, and bone loss in male SD rats.
Shweta ShrivastavaTribhuwan BahugunaSudipto MondalSunil KumarBijo MathewManish Kumar JeengarV G M NaiduPublished in: Immunopharmacology and immunotoxicology (2024)
These findings suggest that CA, through specific enzyme inhibition, offers a compelling alternative therapeutic approach for RA. Further research is warranted to explore the potential of CA in other arthritis models and its suitability for human RA treatment.
Keyphrases
- rheumatoid arthritis
- bone loss
- endothelial cells
- disease activity
- high glucose
- early stage
- ankylosing spondylitis
- signaling pathway
- diabetic rats
- interstitial lung disease
- induced pluripotent stem cells
- systemic lupus erythematosus
- oxidative stress
- climate change
- combination therapy
- idiopathic pulmonary fibrosis
- risk assessment
- replacement therapy