Multidrug resistance proteins preferentially regulate natriuretic peptide-driven cGMP signalling in the heart and vasculature.
Robert M H GrangeMichael E J PreedyAniruthan RenukanthanJoshua P DignamVanessa J LoweAmie J MoyesCristina Pérez-TerneroAisah A AubdoolReshma S BaligaAdrian J HobbsPublished in: British journal of pharmacology (2021)
MRP blockade promotes the cardiovascular functions of natriuretic peptides in vitro and in vivo, with more modest effects on NO. MRP inhibition may have therapeutic utility in cardiovascular diseases triggered by dysfunctional cGMP signalling, particularly those associated with altered natriuretic peptide bioactivity.