MMR profile and microsatellite instability status in colorectal mucinous adenocarcinoma with synchronous metastasis: a new clue for the clinical practice.
Paola ParenteUmberto MalapelleValentina AngerilliMariangela BalistreriSara LonardiSalvatore PucciarelliCaterina De LucaFrancesco PepeGianluca RussoElena VigliarAngela DanzaFabio ScaramuzziGiancarlo TronconePaolo GrazianoAngelo Paolo Dei TosPublished in: Journal of clinical pathology (2022)
Several methodologies are frequently adopted in routine practice to successfully perform MMR/MSI status analysis. The most relevant issues related to MMR/MSI status analysis in MAs concern with low percentage of neoplastic cell and abundant mucine that may affect the molecular analysis. Thus, it might be useful to acquire both primary and metastatic sample to evaluate the MMR/MSI status by integrating IHC evaluation and molecular methodologies to successfully perform molecular profiling for MA patients.
Keyphrases
- clinical practice
- end stage renal disease
- squamous cell carcinoma
- single cell
- healthcare
- primary care
- chronic kidney disease
- prognostic factors
- stem cells
- single molecule
- radiation therapy
- cell therapy
- quality improvement
- bone marrow
- peritoneal dialysis
- patient reported outcomes
- mesenchymal stem cells
- patient reported