Elucidation of the Key Therapeutic Targets and Potential Mechanisms of Marmesine against Knee Osteoarthritis via Network Pharmacological Analysis and Molecular Docking.
Hanbing SongHongpeng LiuXiaodong LiBing LvZonghan TangQipeng ChenDan-Qi ZhangFei WangPublished in: Computational and mathematical methods in medicine (2022)
Marmesine exerts the therapeutic effects against OA through multitarget and multipathways, in which EGFR, CASP3, MMP9, PPARG, and MAPK1 might be hub genes. Our research indicated that the combination of bioinformatics and network pharmacology could serve as an effective approach for investigating the potential mechanisms of natural product.
Keyphrases
- knee osteoarthritis
- molecular docking
- small cell lung cancer
- molecular dynamics simulations
- signaling pathway
- oxidative stress
- network analysis
- human health
- tyrosine kinase
- genome wide
- epidermal growth factor receptor
- gene expression
- dna methylation
- cell proliferation
- pi k akt
- genome wide identification
- cell migration
- genome wide analysis