Epigenetic analysis reveals significant differential expression of miR-378C and miR-128-2-5p in a cohort of relapsed pediatric B-acute lymphoblastic leukemia cases.
Prateek BhatiaMinu SinghAditya SinghPankaj SharmaAmita TrehanNeelam VarmaPublished in: International journal of laboratory hematology (2021)
Our pilot study highlights two miRNAs (miR-128-2-5p and miR-378C) as possible candidate biomarkers of relapsed B-ALL. However, these miRNAs and hypomethylated protooncogene signature noted in our data needs validation in a larger series of B-ALL.
Keyphrases
- data analysis
- acute lymphoblastic leukemia
- cell proliferation
- long non coding rna
- long noncoding rna
- allogeneic hematopoietic stem cell transplantation
- acute myeloid leukemia
- diffuse large b cell lymphoma
- dna methylation
- multiple myeloma
- hodgkin lymphoma
- gene expression
- electronic health record
- big data
- deep learning
- childhood cancer