Single-cell transcriptomics predict novel potential regulators of acute epithelial restitution in the ischemia-injured intestine.

Elizabeth C RoseJeremy M SimonIsmael Gomez-MartinezScott T MagnessJack OdleAnthony T BlikslagerAmanda L Ziegler

Published in: bioRxiv : the preprint server for biology (2024)

These studies validate an approach to identify and predict upstream regulation of restituting epithelium in a unique pig intestinal ischemic injury model. Identification of potential molecular mediators of restitution, such as CSF-1, will inform the development of targeted therapeutic interventions for medical management of patients with ischemia-mediated intestinal injury.

Keyphrases

single cell
rna seq
liver failure
human health
physical activity
high throughput
transcription factor
cancer therapy
intensive care unit
risk assessment
case control
oxidative stress
hepatitis b virus
acute respiratory distress syndrome