GPC3-targeted immunoPET imaging of hepatocellular carcinomas.

Shuxian AnDi ZhangYou ZhangCheng WangLiang ShiWeijun WeiGang HuangJianjun Liu

Published in: European journal of nuclear medicine and molecular imaging (2022)

In the work, we successfully developed sdAb-derived GPC3-targeted immunoPET imaging strategies and characterized the superior diagnostic accuracies in preclinical HCC models. Furthermore, we synthesized a fusion protein ABDG2 with improved targeting and pharmacokinetic properties, serving as a promising candidate for developing radioimmunotherapy agents.

Keyphrases

cancer therapy
high resolution
stem cells
high grade
drug delivery
mass spectrometry
cell therapy
fluorescence imaging
photodynamic therapy