Ratiometric pH-Responsive 19 F Magnetic Resonance Imaging Contrast Agents Based on Hydrazone Switches.
Dawid JanasikKrzysztof JasińskiWładysław P WęglarzIvan NemecPawel JewulaTomasz KrawczykPublished in: Analytical chemistry (2022)
Hydrazone-based molecular switches serve as efficient ratiometric pH-sensitive agents that can be tracked with 19 F NMR/MRI and 1 H NMR. Structural changes induced between pH 3 and 4 lead to signal appearance and disappearance at 1 H and 19 F NMR spectra allowing ratiometric pH measurements. The most pronounced are resonances of the CF 3 group shifted by 1.8 ppm with 19 F NMR and a hydrazone proton shifted by 2 ppm with 1 H NMR.
Keyphrases
- magnetic resonance
- solid state
- high resolution
- magnetic resonance imaging
- fluorescent probe
- contrast enhanced
- living cells
- quantum dots
- sensitive detection
- hydrogen peroxide
- computed tomography
- cystic fibrosis
- diffusion weighted imaging
- mass spectrometry
- oxidative stress
- high glucose
- endothelial cells
- stress induced