Corpus callosum area and brain volume in autism spectrum disorder: quantitative analysis of structural MRI from the ABIDE database.
R Kucharsky HiessR AlterS SojoudiB A ArdekaniR KuznieckyHeath R PardoePublished in: Journal of autism and developmental disorders (2016)
Reduced corpus callosum area and increased brain volume are two commonly reported findings in autism spectrum disorder (ASD). We investigated these two correlates in ASD and healthy controls using T1-weighted MRI scans from the Autism Brain Imaging Data Exchange (ABIDE). Automated methods were used to segment the corpus callosum and intracranial region. No difference in the corpus callosum area was found between ASD participants and healthy controls (ASD 598.53 ± 109 mm(2); control 596.82 ± 102 mm(2); p = 0.76). The ASD participants had increased intracranial volume (ASD 1,508,596 ± 170,505 mm(3); control 1,482,732 ± 150,873.5 mm(3); p = 0.042). No evidence was found for overall ASD differences in the corpus callosum subregions.
Keyphrases
- autism spectrum disorder
- intellectual disability
- attention deficit hyperactivity disorder
- contrast enhanced
- white matter
- magnetic resonance imaging
- computed tomography
- resting state
- high resolution
- machine learning
- emergency department
- magnetic resonance
- high throughput
- multiple sclerosis
- optic nerve
- electronic health record
- cerebral ischemia
- brain injury
- photodynamic therapy
- atomic force microscopy