Imaging tryptophan uptake with positron emission tomography in glioblastoma patients treated with indoximod.

Rimas V LukasCsaba JuhászDerek A WainwrightCharles David JamesEugene KennedyRoger StuppMaciej S Lesniak

Published in: Journal of neuro-oncology (2018)

Here, we have validated the ability to use PET of the Trp probe, AMT, for use in visualizing and quantifying intratumoral Trp uptake in GBM patients treated with an IDO1 pathway inhibitor. These data serve as rationale to utilize AMT-PET imaging in the future evaluation of GBM patients treated with IDO1 enzyme inhibitors.

Keyphrases

pet imaging
positron emission tomography
computed tomography
living cells
pet ct
high resolution
electronic health record
clinical trial
current status
fluorescent probe
fluorescence imaging
photodynamic therapy