Astrocyte lesions in cerebral cortex and cerebellum of dogs with congenital ortosystemic shunting.
Alun WilliamsAdam George GowScott E KilpatrickMichael S TiversVictoria J LipscombKenneth SmithMichael Oliver DayNicholas D JefferyRichard John MellanbyPublished in: Journal of veterinary science (2020)
This study demonstrates that dogs with a cPSS have marked cellular changes in the cerebral cortex and cerebellum. The cellular changes that occur in the cerebral cortex and cerebellum of dogs with spontaneously arising HE are similar to changes which occur in humans with HE, further validating dogs with a cPSS as a good model for human HE.