Mesenchymal Stromal Cells in Osteoarthritis: Evidence for Structural Benefit and Cartilage Repair.
Yujie SongChristian JorgensenPublished in: Biomedicines (2022)
Osteoarthritis (OA) presents a major clinical challenge to rheumatologists and orthopedists due to the lack of available drugs reducing structural degradation. Mesenchymal stromal cells (MSCs) may represent new therapeutic approaches in cartilage regeneration. In this review, we highlight the latest knowledge on the biological properties of MSC, such as their chondrogenic and immunomodulatory potential, and we give a brief overview of the effects of MSCs in preclinical and clinical studies of OA treatment and also compare different MSC sources, with the adipose tissue-derived MSCs being promising. Then, we focus on their structural benefit in treating OA and summarize the current evidence for the assessment of cartilage in OA according to magnetic resonance imaging (MRI) and second-look arthroscopy after MSC therapy. Finally, this review provides a brief perspective on enhancing the activity of MSCs.
Keyphrases
- mesenchymal stem cells
- knee osteoarthritis
- bone marrow
- magnetic resonance imaging
- umbilical cord
- adipose tissue
- extracellular matrix
- cell therapy
- contrast enhanced
- stem cells
- rheumatoid arthritis
- healthcare
- diffusion weighted imaging
- insulin resistance
- metabolic syndrome
- type diabetes
- high fat diet
- drinking water
- risk assessment
- replacement therapy
- magnetic resonance
- wound healing
- smoking cessation