PRC2 represses transcribed genes on the imprinted inactive X chromosome in mice.

Emily MaclaryMichael HintenClair HarrisShriya SethuramanSrimonta GayenSundeep Kalantry

Published in: Genome biology (2017)

A comparative analysis of transcriptional and chromatin features of inactive X-linked genes in WT and Eed -/- TSCs suggests that PRC2 acts as a brake to prevent induction of transcribed genes on the inactive X chromosome, a mode of PRC2 function that may apply broadly.

Keyphrases

genome wide
genome wide identification
gene expression
transcription factor
bioinformatics analysis
copy number
dna damage
type diabetes
mass spectrometry
metabolic syndrome
oxidative stress
heat shock
wild type
liquid chromatography