Arginase-2-specific cytotoxic T cells specifically recognize functional regulatory T cells.
Stine Emilie Weis-BankeThomas Landkildehus LisleMaria Perez-PencoAimilia SchinaMie Linder HübbeMajken SiersbækMorten Orebo HolmströmMia Aaboe JørgensenInge Marie SvaneÖzcan MetNiels ØdumDaniel Hargbøl MadsenMarco DoniaLars GrøntvedMads Hald AndersenPublished in: Journal for immunotherapy of cancer (2022)
These findings highlight the ability of ARG2-specific T cells to modulate the immunosuppressive TME and suggest that ARG2-based immunomodulatory vaccines may be an interesting option for cancer immunotherapy.