The pre-conception maternal exposure to Sofosbuvir affects the mitochondrial biogenesis in prenatal fetal tissues: Experimental study on rats.
Shimaa A MahmoudMaryam M Abdel-AzizRana H M KhafagaHala A HafezMaher A KamelSara A ShakerPublished in: Molecular medicine (Cambridge, Mass.) (2023)
The study provides preliminary evidence of the detrimental effects of Sofosbuvir on the pregnancy outcomes of the exposed females and may impair the placental and fetal organs' development. These effects may be mediated through modulating mitochondrial homeostasis and functions.