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CB2-mediated attenuation of nucleus pulposus degeneration via the amelioration of inflammation and oxidative stress in vivo and in vitro.

Xiaoqiang ChengJiayi LinZhanghuan ChenYubo MaoXiexin WuCongxin XuJiacheng DuZhongchen DongHuilin YangFeng ZhouDechun Geng
Published in: Molecular medicine (Cambridge, Mass.) (2021)
The experiment indicates the oxidative stress and inflammatory response of rat NPCs induced by H2O2 could be inhibited by activating CB2. This study reveals that CB2 activation can effectively delay the development of IVDD, providing an effective therapeutic target for IVDD.
Keyphrases
  • oxidative stress
  • inflammatory response
  • diabetic rats
  • dna damage
  • ischemia reperfusion injury
  • induced apoptosis
  • signaling pathway
  • lipopolysaccharide induced
  • heat shock
  • lps induced
  • toll like receptor