Cerebral compensation during motor function in Friedreich ataxia: The IMAGE-FRDA study.

Ian H HardingLouise A CorbenMartin B DelatyckiMonique R StagnittiElsdon StoreyGary F EganNellie Georgiou-Karistianis

Published in: Movement disorders : official journal of the Movement Disorder Society (2017)

Compensatory activity is evident in the cerebral cortex in individuals with Friedreich ataxia. Early compensation followed by later decline in premotor/ventral attention systems demonstrates capacity-limited neural reserve, while the additional engagement of higher order brain networks is indicative of compensatory task strategies. Network-level changes in cerebral brain function thus potentially serve to mitigate the impact of motor impairments in Friedreich ataxia. © 2017 International Parkinson and Movement Disorder Society.

Keyphrases

cerebral ischemia
subarachnoid hemorrhage
early onset
resting state
functional connectivity
white matter
brain injury
spinal cord
social media
deep learning
working memory