Surfactant cocamide monoethanolamide causes eye irritation by activating nociceptor TRPV1 channels.

Fang Zhao Shuangyan Wang Yan-Yan Li Jin Wang Yujing WangChunlei ZhangYong LiLongjiang HuangYe Yu Jie Zheng Bo-Yang Yu Isaac N Pessah Zheng-Yu Cao

Published in: British journal of pharmacology (2021)

CMEA directly activates TRPV1 channels to produce eye irritation. Rabbits, the standard animal used for eye irritancy tests are poor models for evaluating human eye irritants structurally related to CMEA. Our study identifies potential alternatives to CMEA as non-irritating surfactants.

Keyphrases

endothelial cells
signaling pathway
gene expression
risk assessment
induced pluripotent stem cells
human health