Knockdown of the prognostic cancer stem cell marker Musashi-1 decreases radio-resistance while enhancing apoptosis in hormone receptor-positive breast cancer cells via p21WAF1/CIP1.

Fabian Martin TroschelHeike PalentaKatrin BorrmannKristin HesheSan Hue HuaWai-Cheong George YipLudwig KieselHans Theodor EichMartin Götte Burkhard Greve

Published in: Journal of cancer research and clinical oncology (2021)

MSI-1 is a prognostic marker in breast cancer. MSI-1 silencing downregulates proliferation while increasing apoptosis. The anti-proliferation mediator p21 was upregulated independently after both MSI-1 knockdown and irradiation and even more after both treatments combined, suggesting synergistic potential. Radio-sensitization effects after combining radiation and MSI-1 knockdown underline the potential of MSI-1 as a therapeutic target.

Keyphrases

oxidative stress
cancer stem cells
endoplasmic reticulum stress
breast cancer cells
signaling pathway
cell cycle arrest
cell death
radiation induced
risk assessment
pi k akt