Neuroprotective Effects of Quercetin in Pediatric Neurological Diseases.
Lourdes Alvarez-ArellanoMarcela Salazar-GarcíaJuan Carlos CoronaPublished in: Molecules (Basel, Switzerland) (2020)
Oxidative stress is a crucial event underlying several pediatric neurological diseases, such as the central nervous system (CNS) tumors, autism spectrum disorder (ASD) and attention-deficit/hyperactivity disorder (ADHD). Neuroprotective therapy with natural compounds used as antioxidants has the potential to delay, ameliorate or prevent several pediatric neurological diseases. The present review provides an overview of the most recent research outcomes following quercetin treatment for CNS tumors, ASD and ADHD as well as describes the potential in vitro and in vivo ameliorative effect on oxidative stress of bioactive natural compounds, which seems like a promising future therapy for these diseases. The neuroprotective effects of quercetin against oxidative stress can also be applied in the management of several neurodegenerative disorders with effects such as anti-cancer, anti-inflammatory, anti-viral, anti-obesity and anti-microbial. Therefore, quercetin appears to be a suitable adjuvant for therapy against pediatric neurological diseases.
Keyphrases
- attention deficit hyperactivity disorder
- autism spectrum disorder
- oxidative stress
- intellectual disability
- cerebral ischemia
- working memory
- dna damage
- metabolic syndrome
- ischemia reperfusion injury
- blood brain barrier
- sars cov
- type diabetes
- anti inflammatory
- early stage
- weight loss
- skeletal muscle
- induced apoptosis
- young adults
- brain injury
- climate change
- current status
- weight gain
- diabetic rats
- stem cells
- mesenchymal stem cells
- cerebrospinal fluid
- smoking cessation