Undirected biocatalytic amination of unactivated C( sp 3 )-H bonds.

Selective catalytic functionalization of C( sp 3 )-H bonds represents a powerful means to access valuable products from ubiquitous starting materials. In a recent JACS paper, Arnold and co-workers engineered P450 nitrene transferases to aminate unactivated C( sp 3 )-H bonds with excellent site- and stereoselectivities.