Development of a Novel Technique for the Measurement of Neuromuscular Junction Functionality in Isotonic Conditions.
Flavia ForconiLudovica ApaSimona PisuIrene CasolaAntonio MusaròEmanuele RizzutoZaccaria Del PretePublished in: Cellular and molecular bioengineering (2022)
In this work we devised a novel technique and a new parameter for a deep assessment of NMJ functionality in isotonic conditions, including fatigue, which is the most crucial condition for the neuronal signal transmission. This technique may be applied to other animal models, to unravel the mechanisms behind muscle-nerve impairments in other neurodegenerative pathologies.