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Murine Mammary Carcinoma Induces Chronic Systemic Inflammation and Immunosuppression in BALB/c Mice.

Dasha FuentesAlejandro Cabezas-CruzCirce MesaTania CarmenateDarel MartínezAnet Valdés-ZayasEnrique MonteroRolando Pérez
Published in: Journal of breast cancer (2022)
These results support the occurrence of F3II tumor-mediated immune cell dysfunction, which mimics the immune alterations characterized by chronic systemic inflammation and immunosuppression observed in breast cancer in clinical settings. Thus, the F3II tumor model is relevant for evaluating novel breast cancer immunotherapies and combinations in preclinical studies. This model could also be useful for identifying appropriate therapeutic targets and developing proof-of-concept experiments in the future.
Keyphrases
  • risk assessment
  • oxidative stress
  • type diabetes
  • current status
  • cell therapy
  • drug induced
  • skeletal muscle
  • metabolic syndrome
  • childhood cancer