Linking autism spectrum disorders and parkinsonism: clinical and genetic association.

Aaron Shengting MaiChun En YauFan Shuen TsengQi Xuan Joel FooDennis Qing Wang Eng-King Tan

Published in: Annals of clinical and translational neurology (2023)

The prevalence of parkinsonism in ASD is substantially greater than in the general population or matched controls. Various PD-associated gene loci, especially PARK2, could confer susceptibility to ASD as well. Important future directions include conducting prospective cohort studies to understand how parkinsonian symptoms may progress, genetic studies to reveal relevant gene loci, and pathophysiologic studies to identify potential therapeutic targets.

Keyphrases

genome wide
autism spectrum disorder
dna methylation
copy number
attention deficit hyperactivity disorder
intellectual disability
parkinson disease
case control
risk factors
gene expression
current status
climate change
human health