Molecular and immune correlates of TIM-3 (HAVCR2) and galectin 9 (LGALS9) mRNA expression and DNA methylation in melanoma.

Tobias A W HolderriedLuka de VosEmma Grace BawdenTimo J VogtJoern DietrichRomina ZarblFriedrich BootzGlen KristiansenPeter BrossartJennifer LandsbergDimo Dietrich

Published in: Clinical epigenetics (2019)

Our study points toward an epigenetic regulation of TIM-3 and LGALS9 via DNA methylation and might provide an avenue for the development of a predictive biomarker for response to immune checkpoint blockade.

Keyphrases

dna methylation
genome wide
gene expression
copy number
single molecule