Uptake of platelets by cancer cells and recycling of the platelet protein CD42a.
Nadine Martins CastanheiraAnna K SpanhoferSebastian WienerStefanie BobeHermann SchillersPublished in: Journal of thrombosis and haemostasis : JTH (2021)
Our results demonstrate that cancer cells hijack platelets by phagocytosis and recycling of platelet membrane proteins. The uptake of platelets has additional advantages for cancer cells: access to the entire and undiluted platelet proteome, transcriptome, and secretome. These novel findings will allow further mechanistic elucidation and thus help us gain deeper insights into platelet-assisted hematogenous metastasis.
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