Brain Metabolism and Structure in Chronic Migraine.
Kuan-Lin LaiShuu-Jiun WangPublished in: Current pain and headache reports (2020)
Spectroscopic and structural MRI studies have shown the presence of both impaired metabolism and structural alterations in the brain of CM patients. Metabolic changes in key brain regions support the notion of altered energetics and homeostasis as part of CM pathophysiology. Furthermore, CM, like other chronic pain disorders, may undergo structural reorganization in pain-related brain regions following near persistent endogenous painful input. Finally, both imaging techniques may provide potential biomarkers of disease state and progression and may help guide novel therapeutic interventions or strategies. Spectroscopic and structural MRI have revealed novel aspects of CM pathophysiology. Findings from the former support the metabolic theory of migraine pathogenesis.
Keyphrases
- chronic pain
- resting state
- white matter
- functional connectivity
- magnetic resonance imaging
- molecular docking
- cerebral ischemia
- end stage renal disease
- contrast enhanced
- ejection fraction
- newly diagnosed
- pain management
- computed tomography
- prognostic factors
- high resolution
- chronic kidney disease
- blood brain barrier
- spinal cord
- magnetic resonance
- neuropathic pain
- patient reported outcomes