Affective Disturbances During Withdrawal from Chronic Intermittent Ethanol Inhalation in C57BL/6J and DBA/2J Male Mice.

Harpreet SidhuMax KreifeldtCandice Contet

Published in: Alcoholism, clinical and experimental research (2018)

Our results indicate that withdrawal from CIE elicits negative emotionality in both C57 and DBA mice, but different tests need to be used to measure the anxiogenic-like effects of withdrawal in each strain. Increased digging activity and irritability-like behavior represent novel indices of affective dysfunction associated with withdrawal from CIE in both mouse strains. Our findings enrich the characterization of the affective symptomatology of protracted withdrawal from CIE in mice.

Keyphrases

bipolar disorder
high fat diet induced
oxidative stress
type diabetes
metabolic syndrome
insulin resistance
drug induced