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Loss of SETD2 aggravates colorectal cancer progression caused by SMAD4 deletion through the RAS/ERK signalling pathway.

Chunxiao MaMin LiuWenxin FengHanyu RaoWei ZhangChangwei LiuYue XuZiyi WangYan TengXiao YangLi NiJin XuWei-Qiang GaoBing LuLi Li
Published in: Clinical and translational medicine (2023)
Our results demonstrated that SETD2 inhibits the RAS/ERK signaling pathway by facilitating the transcription of DUSP7 in SMAD4-deficient CRC, which could provide a potential therapeutic target for the treatment of advanced CRC.
Keyphrases
  • signaling pathway
  • epithelial mesenchymal transition
  • pi k akt
  • wild type
  • transforming growth factor
  • cell proliferation
  • induced apoptosis
  • transcription factor
  • oxidative stress
  • climate change
  • replacement therapy