Influence of CASP9 c.-1339A>G and CASP3 c.-1191A>G variants in outcome of patients with head and neck squamous cell carcinoma.

Bruna Fernandes CarvalhoEricka Francislaine Dias CostaLeisa Lopes-AguiarVitor Teixeira LiuttiFrederico LealVivian Castro Antunes VasconcelosJosé Augusto Rinck-JuniorGustavo Jacob Lourenço Carmen Silvia Passos Lima

Published in: Journal of oral pathology & medicine : official publication of the International Association of Oral Pathologists and the American Academy of Oral Pathology (2020)

Our findings provide, for the first time, preliminary evidence that inherited abnormalities in the intrinsic apoptosis pathway, related to CASP9 c.-1339A>G and CASP3 c.-1191A>G SNVs, act as predictors of HNSCC patients' survival.

Keyphrases

end stage renal disease
chronic kidney disease
newly diagnosed
ejection fraction
peritoneal dialysis
cell death
endoplasmic reticulum stress
copy number
dna methylation
patient reported outcomes
cell cycle arrest
cell proliferation
free survival