Yeast cells can partially revert chromosome segregation to repair late DNA double-strand breaks through homologous recombination.
Jessel Ayra-PlasenciaFélix MachínPublished in: Molecular & cellular oncology (2019)
DNA repair in late mitosis sets paradoxical scenarios. Cyclin-dependent kinase (CDK) activity is high, which favors homologous recombination (HR), despite a sister chromatid is not physically close to recombine with. We have found that DNA double-strand breaks partially revert chromosome segregation to find an intact template and repair through HR.
Keyphrases
- dna repair
- dna damage
- circulating tumor
- cell cycle arrest
- cell cycle
- cell free
- induced apoptosis
- single molecule
- dna damage response
- copy number
- climate change
- cell death
- pi k akt
- protein kinase
- nucleic acid
- circulating tumor cells
- gene expression
- oxidative stress
- signaling pathway
- saccharomyces cerevisiae
- endoplasmic reticulum stress
- mass spectrometry
- dna methylation
- molecularly imprinted
- tandem mass spectrometry