Combination of ultrasound-based mechanical disruption of tumor with immune checkpoint blockade modifies tumor microenvironment and augments systemic antitumor immunity.
Shinya AbeHiroshi NagataErika J CrosbyYoshiyuki InoueKensuke KanekoCong-Xiao LiuXiao YangTao WangChaitanya R AcharyaPankaj AgarwalJoshua SnyderWilliam GwinMichael A MorsePei ZhongHerbert Kim LyerlyTakuya OsadaPublished in: Journal for immunotherapy of cancer (2022)
Physical disruption of the TME by M-HIFU repolarizes TAM, enhances T-cell infiltration, and, when combined with anti-PD-L1 antibody, mediates superior systemic antitumor immune responses and distant tumor growth suppression. These findings suggest M-HIFU combined with anti-PD-L1 may be useful in reducing late recurrence or metastasis when applied to primary tumors.