Limited influence of germline genetic variation on all-cause mortality in women with early onset breast cancer: evidence from gene-based tests, single-marker regression, and whole-genome prediction.

Molly Scannell BryanMaria ArgosIrene L AndrulisJohn L HopperJenny Chang-ClaudeKathleen MaloneEsther M JohnMarilie D GammonMary DalyMary Beth TerrySaundra S BuysDezheng HuoOlofunmilayo OlopadeJeanine M GenkingerFarzana JasmineMuhammad G KibriyaLin ChenHabibul Ahsan

Published in: Breast cancer research and treatment (2017)

Despite multiple complementary approaches, our study found no evidence that mortality in women with early onset breast cancer is influenced by germline variation.

Keyphrases

early onset
late onset
dna repair
cardiovascular events
genome wide
risk factors
type diabetes
cardiovascular disease
gene expression
coronary artery disease