Angiopoietin-2/-1 ratios and MMP-3 levels as an early warning sign for the presence of giant cell arteritis in patients with polymyalgia rheumatica.

Yannick van SleenPhilip TherkildsenBerit Dalsgaard NielsenKornelis S M van der GeestIb HansenPeter HeeringaMarcel D PosthumusMaria SandoviciErik J M ToonenJannik ZijlstraAnnemieke M H BootsEllen-Margrethe HaugeElisabeth Brouwer

Published in: Arthritis research & therapy (2022)

This study, performed in two independent international cohorts, consistently shows the potential of angiopoietin-2/-1 ratios and MMP-3 levels to identify GCA in patients presenting with PMR. These biomarkers may be used to select which PMR patients require further diagnostic workup. Platelet counts may be used to discriminate GCA from GCA look-alike patients.

Keyphrases

giant cell
end stage renal disease
ejection fraction
newly diagnosed
chronic kidney disease
prognostic factors
climate change