Fragment Ends of Circulating Microbial DNA as Signatures for Pathogen Detection in Sepsis.
Guangya WangW K Jacky LamLowell LingMary-Jane L MaSaravanan RamakrishnanDon C T ChanWing-Shan LeeSuk Hang ChengRebecca W Y ChanStephanie C Y YuIrene O L TseWai Tat WongPeiyong JiangRossa W K ChiuK C Allen ChanY M Dennis LoPublished in: Clinical chemistry (2023)
The use of fragmentomic features could facilitate the differentiation of underlying contaminating microbes from true pathogens in sepsis. This work demonstrates the potential usefulness of microbial cfDNA fragmentomics in metagenomics analysis.