Cordyceps militaris induces apoptosis in ovarian cancer cells through TNF-α/TNFR1-mediated inhibition of NF-κB phosphorylation.

Eunbi JoHyun-Jin JangKyeong Eun YangMin Su JangYang Hoon HuhHwa-Seung YooJun Soo ParkIk-Soon JangSoo Jung Park

Published in: BMC complementary medicine and therapies (2020)

These results suggest that C. militaris inhibited ovarian cancer cell proliferation, survival, and migration, possibly through the coordination between TNF-α/TNFR1 signaling and NF-κB activation. Taken together, our findings provide a new insight into a novel treatment strategy for ovarian cancer using C. militaris.

Keyphrases

signaling pathway
cell proliferation
pi k akt
rheumatoid arthritis
lps induced
oxidative stress
nuclear factor
cell cycle
inflammatory response
protein kinase