Fano Resonance-Based Blood Plasma Monitoring and Sensing using Plasmonic Nanomatryoshka.

The fast label-free detection of specific antibodies and their concentration in blood plasma is useful for many applications, e.g., in Covid-19 patients. The change in biophysical properties like the refractive index of blood plasma due to the production of antibodies during infection may be very helpful in estimating the level and intensity of infection and subsequent treatment based on blood plasma therapy. In this article, Fano resonance-based refractive index sensor using plasmonic nanomatryoshka is proposed for blood plasma sensing. The interaction between hybridized modes (bright and dark modes) in optimized nanomatryoshka leads to Fano resonance, which by virtue of steeper dispersion can confine the light more efficiently compared with Lorentzian resonance. We propose the excitation of Fano resonances in sub 100-nm size nanomatryoshka based on newly emerging plasmonic materials ZrN and HfN, and one of the most widely used conventional plasmonic material, Au. Fano resonance-based plasmonic sensors leads to sensitivity = 188.5 nm/RIU, 242.5 nm/RIU, and 244.9 nm/RIU for Au, ZrN, and HfN, respectively. The corresponding figure of merit (nm/RIU) is ~ 3.5  ×  103, 3.1  ×  103, and 2.8  ×  103 for Au, ZrN, and HfN, respectively. Present theoretical analysis shows that refractive index sensors with high sensitivity and figure of merit are feasible using Fano modes of plasmonic nanomatryoshka.